Risk factors for penile prosthesis infection: An umbrella review and meta-analysis

Background As available data on implantation-related infections is contradictory, the aim was to identify predictors of penile prosthesis infection.Methods We performed an umbrella review and meta-analysis including systematic reviews with extractable data. Literature search done in two databases: PubMed Google Scholar. The participants were males erectile dysfunction regardless etiology who underwent implant surgery. Using a standardized form, three trained researchers reviewed each reference (systematic review) by title abstract. using Review Manager 5.4.1 (RevMan® 5.4.1).Results A total 78 identified strategies. Of these, 35 duplicates removed. Thirty-seven full-text then excluded after revision. Six 271,226 patients (156,553 study group 114,673 control group) included meta-analysis. analysis various adverse outcomes (infection). Among them glycated hemoglobin (HbA1c) different characteristics implants.Conclusions revealed significant risk factors/predictors infection: levels; reoperation, associated type prosthesis. weighted mean HbA1c levels without 8.37% 7.17% respectively. OR as follows: first surgery/revision 0.36 (95% CI 0.29–0.45); antibiotic-coated/non-coated 0.47 0.31–0.72); malleable/inflatable 3.51 1.41–8.74).